Biosynthesis of digitoxin in Digitalis purpurea []. Deluca, M.E. Seldes, A.M. Gros, E.G. (Departamento de Quimica Organica, Universidad de Buenos Aires. Download Citation on ResearchGate | Biosynthesis of digitoxin in Digitalis purpurea | Simultaneous administration of a mixture of [H]-3β. Deluca M.E.; Seldes A.M.; Gros E.G., Biosynthesis of digitoxin in digitalis purpurea.
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Studies in the genus Digitalis. Determination of the digitoxin content of Digitalis purpurea. Effects of nutrients on digitoxin formation by shoot-forming cultures of Digitalis purpurea L.
Comparative study of the biology of digitalis biosythesis digitalis ambigua digitalis purpurea and a digitalis purpurea inoculated population. The Yale Journal of Biology and Medicine. Planta Medica 17 4: Ouabain g-Strophanthin k-Strophanthin Cymarin. Digitoxin is a cardiac glycoside.
Investigations on the biosynthesis of digitalis d glycosides enzymatic glycosylation of digitoxin by a particulate enzyme fraction of digitalis purpurea d. Alcoholic glycoside Cardiac glycoside Bufadienolide Cardenolide Cyanogenic glycoside Glycosylamine Phenolic glycoside Anthraquinone glycoside Coumarin glycoside Flavonoid glycoside Saponin Steviol glycoside Thioglycoside. Incidence and biosynthesis of cardenolides in tissue cultures of Digitalis purpurea and Digitalis lanata.
Digitoxin and related cardenolides display potent anticancer activity against a range of human cancer cell lines in vitro but the clinical use of digitoxin to treat cancer has been restricted by its narrow therapeutic index. Studies on the production of Digitalis cardenolides by plant tissue culture. The colorimetric estimation of digitoxin and of preparations of Digitalis purpurea. Journal of Pharmacy and Pharmacology 8 Cardenolides in surface-cultures of cotyledones and leaves of Digitalis purpurea.
Studies on the production of digitalis cardenolides by plant tissue culture 3.
PDF of Biosynthesis of digitoxin in digitalis purpurea
Oswald Schmiedeberg was able to obtain a pure sample in Cardiac glycosides and cancer therapy”. This page was last edited on 20 Septemberat Quantitative determination of digitoxin and gitoxin in digitalis purpurea.
Journal of Pharmacy and Pharmacology 4 In other projects Wikimedia Commons. The modern therapeutic use of this molecule was made possible by the works of the pharmacist and the French chemist Claude-Adolphe Nativelle It is a phytosteroid and is similar in structure and effects to digoxin though the effects idgitoxin longer-lasting. By using this site, you agree to the Terms of Use and Privacy Policy.
The first structural analysis was done by Adolf Otto Reinhold Windaus inbut the full structure with an exact determination of the sugar groups was not accomplished until Plant and Cell Physiology 23 7: Chemistry of natural compounds: Retrieved from ” https: Biosynthesis of digitoxin in digitalis purpurea. European Journal of Clinical Bkosynthesis. Enzymatic glucosylation of digitoxin by particle enzyme fractions dibitoxin Digitalis purpurea.
Khimiko-Farmatsevticheskii Zhurnal 5 Biosynthesis of digitalis glycosides. While several controlled trials have shown digoxin to be effective in a proportion of patients treated for heart failure, the evidence base for digitoxin is not as strong, although it digitooxin presumed to be similarly effective.
However, it is now rarely used in current Western medical practice. Views Read Edit View history.
Biosynthesis of digitoxin in Digitalis purpurea [1989]
Arenobufagin Bufotalin Cinobufagin Marinobufagin. Quantitative determination of digitoxin and gitoxin in the leaves of Digitalis purpurea. Planta Medica 29 3: Transl9 5 Industrial lyophilization tests of medicinal plants vi purple digitalis d digitalis purpurea d digitoxin glucoside. Planta Medica 46 2: O-glycosidic bond N-glycosidic bond S-glycosidic bond C-glycosidic bond.
From Wikipedia, the free encyclopedia. Determination of digitoxin and other glycosides and genins in Digitalis purpurea.
Antidigoxin antibody fragments, the specific treatment for digoxin poisoning, are also effective in serious digitoxin toxicity. Comparative investigation of the biology of Digitalis lanata, Digitalis ambigua, Digitalis purpurea and Digitalis purpurea grafted population.
Biosynthesis of digitoxin in Digitalis purpurea
With Practical Remarks on Dropsy and other Diseases. Biotransformation of digitoxin by suspension callus culture of Digitalis purpurea. The first description of the use of foxglove dates back to Annales Pharmaceutiques Francaises 25 Digitoxin exhibits similar toxic effects to the more commonly used digoxinnamely: